Literature Review
Phytochemical and Pharmacological Studies in Justicia wynaadensis, an Ethnomedicinal Plant: A Comprehensive Review
Published 2024-07-08
Keywords
- <i>Justicia wynaadensis</i>, Phytochemistry, Antioxidant, Antimicrobial, Anti-inflammatory
How to Cite
M. N., I., Mishra, A., & R., K. (2024). Phytochemical and Pharmacological Studies in <i>Justicia wynaadensis</i>, an Ethnomedicinal Plant: A Comprehensive Review. Kristu Jayanti Journal of Core and Applied Biology (KJCAB), 3(1), 26–30. https://doi.org/10.59176/kjcab.v3i1.2365
Abstract
Justicia wynaadensis (Nees) T. Anderson., an ethno medicinal plant of western Ghats is of immense medicinal value. Commonly called Maddhu Thoppu, in Coorg (Kodagu) District of Karnataka, the plant is reiigiously used by the folkflore to gain immunity against local diseases. J. wynaadensis possesses a wide range of medicinal properties which also include anti-inflammatory, antimicrobial, animutagenic and antioxidant activity. Based on the medicinal properties, J. wynaadensis is a potential plant that that can used as a phyto drug. It has been observed that on 18th day of Aati masa or Kakkada, the medicinal properties of Justicia wynaadensis escalates its peak. Consumption of the plant on this day is believed to provide more health benefits. This review summarizes the literature based on pharmacological, phytochemical and medicinal uses of J. wynaadensis with the purpose of finding gaps demanding for future research and further investigating its potential as an herbal drug.
Downloads
Download data is not yet available.
References
Abhishek M, Kirti J, Somashekaraiah, BV, Saraswathi Raman DN (2014). Phytochemical Composition and InVitro Antioxidant Activity of Justicia wynaadensis Leaves. Int. J. Inn. Res. in Sci. Engn. Tech. 4(9): 8235-8342.
Carneiro MRB, Sallum LO, Martins JLR, Peixoto JdC, Napolitano HB, Rosseto LP (2023). Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential. Molecules. 28(3): 1190.
Dorin Dsouza and Lakshmidevi Nanjaiah (2017) Wound healing activity of 3, 3', 4'-Trihydroxyflavone, isolated from Justicia wynaadensis. Wound Medicine, 19: 10-14.
Dorin Dsouza, Lakshmidevi N. (2018). Antibacterial activity of 3,3',4'-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection. Brazilian J. Microbiol. 49(1): 152-161.
Farhan Z, Rukmangada MS, Jyoti BC, Shaukath, AK, Pramod K, Aishwarya TD, Nagendra Prasad MN, Dhananjaya, BL (2016). Evaluation of adhesive and antiadhesive properties of Pseudomonas aeruginosa biofilms and their inhibition by herbal plants. Iranian J. Micro. 8(2): 108-119.
Gamble JS (1967). Flora of the Presidency of Madras. Adlard and Sons Ltd., London. II: pp. 755-756.
Hemanth Kumar NK, Devabrath AJ, Manjunatha S, Murali M, Amruthesh KN, Shobha J. (2019). Antimitotic and DNA-binding potential of biosynthesized ZnO-NPs from leaf extract of Justicia wynaadensis (Nees) Heyne A medicinal herb. Biocatalysis and Agri. Biotech. 18.
Indira MN (2022). GC-MS analysis of bioactive compounds in ethanolic extract of Drymaria cordata (L.) Willd. ex Roem. & Schult. Res. J. Pharm. Techn. 15(9): 4192-5.
John B, Reddy VRK, Sulaiman CT (2013). Total Phenolics and Flavonoids in Selected Justicia species. J. Pharm. Phytochem. 2(4):72-73.
John B, Sulaiman CT, George S, Reddy VRK (2014). Spectrophotometric estimation of total alkaloids in selected Justicia species. Int. J. Pharm. and Pharmaceutical sci. 6(5): 647-648.
Karunakaran G, Azeez S, Tripathi PC, Sakthivel T, Arivalagan M, Prasath D, Sankar V, Kumar RS. Temporal changes of phenolics, flavonoids, carotenoids and mineral constituents in the leaf of a medicinal plant Justicia wynaadensis. J. Envn. Biol. 43:694-70
Lava MB, Uday M, Muddapur, Nagaraj B, Sunil SM, Veena SM (2021). Characterization, anticancer, antibacterial, anti-diabetic and anti-inflammatory activities of green synthesized silver nanoparticles using Justica wynaadensis leaves extract. Materials Today: Proceedings, 46(13): 5942-5947.
Lingaraju D, Sudarshana M, Rajashekar N (2013). Ethnopharmacological Survey of Traditional Medicinal Plants in Tribal areas of Kodagu District, Karnataka, India. J. Pharm. Res. 6: 284-297.
Luzia KAML, Aline HS, Glauce Socorro de Barros Viana (2017). Justicia pectoralis, a coumarin medicinal plant have potential for the development of antiasthmatic drugs? Revista Brasileira de Farmacognosia. 27(6): 794-802.
Nigudkar M, Patil N, Sane R and Datar A (2014). Preliminary phytochemical screening and HpTLC fingerprinting analysis of Justicia wynaadensis (Nees) And. Int. J. Pharma Sci. 4(3): 601-605.
Patil N, Nigudkar M, Sane R, Ajitkumar BS, Datar A (2015). Evaluation of microscopic structure of Justicia wynaadensis and the stability of its color extracted by using conventional and microwave extraction method. J Food Sci. Technol. 52(10): 6455-64.
Ponnamma S and Manjunath K (2012). High frequency induction and regeneration of multiple shoots from nodal explants of Justicia wynaadensis (Nees) T. Anders Int. J. Curr. Res. 4: 40-43.
Ponnamma SU and Manjunath K (2012). GC-MS Analysis of Phytocomponents in the Methanolic Extract of Justicia Wynaadensis (Nees) T. Anders. Int. J. Pharm. Bio Sci. 3(3): 570 - 576.
Ponnamma SU and Manjunath K (2015). TLCBioautography guided screening for compounds inhibitory to Klebsiella pneumonia from Justicia wynaadensis (Nees) T.Anders. Ind. J. of Appl. Res. 5(4).
Sahana Chavan CS, Ramakrishna R, Saraswathi Raman DN, Somashekaraiah BV (2019). Phytochemical analysis and in vitro antioxidant activity of extracts of Justicia wynaadensis leaves. Research J. Pharm. and Tech. 12(8): 3643-3648.
Saini V, Gangwar LD. (2023). A Review Article for Medicinal uses of Justicia wynaadensis. International Journal of Pharmaceutical Research and Applications. 8(1):1573-1576
Subbiah MTR, Norman EJ (2002). Rain Forest Plant Extract with Cellular Cholesterol Lowering Properties. United States Patent, 6: 365-411.
Sudha M, Geetha RJ Singh, Vaishnavi R (2011). The phytochemical and antioxidant screening of Justicia wynaadensis. African J. Plant Sci. 5(9):489-492.
Sujatha SS and Thrupthi N (2020). Review Literature on Justicia wynaadensis. Int. J. Adv. Res. Inn. Ideas in Educ. 6(4): 1503-1507.
Vandana CD and Shanti KN (2017). Cytotoxic activity of Justicia wynaadensis (Nees) T. Anderson leaf extract on Human Cancer Cell lines. Int. J. Pharm. Sci. Res. 8(12): 5298-5302.
Vandana CD, Shanti KN, Shantha SL (2018). GC-MS analysis of callus and leaf extracts of in vitro propagated plants of Justicia wynaadensis (Nees) T. Anderson. Int. J. Pharm. Sci. Res. 9(2): 535-543.
Vandana CD, Shanti, KN, Prashantha K Vivek C (2020). In silico studies of bioactive phytocompounds with anticancer activity from in vivo and in vitro extracts of Justicia wynaadensis (Nees) T. Anderson. Int. J. Comp. Biol. Drug Desn. 13:5-6.
Vidyabharathi BP (2012). Assessment of antiinflammatory activity of Justicia wynaadensis, a medicinal plant. International Conference on Biodiversity and Sustainable Energy Development, Hyderabad International Convention Center, India.
Vishma BL, Sujayraj RS, Prashantha N (2015). Antioxidant and Genoprotective studies of the leaf extract of Justicia wynaadensis (Nees) in Conference: National Seminar on Life and Life Processes: Sustainable Development.
Carneiro MRB, Sallum LO, Martins JLR, Peixoto JdC, Napolitano HB, Rosseto LP (2023). Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential. Molecules. 28(3): 1190.
Dorin Dsouza and Lakshmidevi Nanjaiah (2017) Wound healing activity of 3, 3', 4'-Trihydroxyflavone, isolated from Justicia wynaadensis. Wound Medicine, 19: 10-14.
Dorin Dsouza, Lakshmidevi N. (2018). Antibacterial activity of 3,3',4'-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection. Brazilian J. Microbiol. 49(1): 152-161.
Farhan Z, Rukmangada MS, Jyoti BC, Shaukath, AK, Pramod K, Aishwarya TD, Nagendra Prasad MN, Dhananjaya, BL (2016). Evaluation of adhesive and antiadhesive properties of Pseudomonas aeruginosa biofilms and their inhibition by herbal plants. Iranian J. Micro. 8(2): 108-119.
Gamble JS (1967). Flora of the Presidency of Madras. Adlard and Sons Ltd., London. II: pp. 755-756.
Hemanth Kumar NK, Devabrath AJ, Manjunatha S, Murali M, Amruthesh KN, Shobha J. (2019). Antimitotic and DNA-binding potential of biosynthesized ZnO-NPs from leaf extract of Justicia wynaadensis (Nees) Heyne A medicinal herb. Biocatalysis and Agri. Biotech. 18.
Indira MN (2022). GC-MS analysis of bioactive compounds in ethanolic extract of Drymaria cordata (L.) Willd. ex Roem. & Schult. Res. J. Pharm. Techn. 15(9): 4192-5.
John B, Reddy VRK, Sulaiman CT (2013). Total Phenolics and Flavonoids in Selected Justicia species. J. Pharm. Phytochem. 2(4):72-73.
John B, Sulaiman CT, George S, Reddy VRK (2014). Spectrophotometric estimation of total alkaloids in selected Justicia species. Int. J. Pharm. and Pharmaceutical sci. 6(5): 647-648.
Karunakaran G, Azeez S, Tripathi PC, Sakthivel T, Arivalagan M, Prasath D, Sankar V, Kumar RS. Temporal changes of phenolics, flavonoids, carotenoids and mineral constituents in the leaf of a medicinal plant Justicia wynaadensis. J. Envn. Biol. 43:694-70
Lava MB, Uday M, Muddapur, Nagaraj B, Sunil SM, Veena SM (2021). Characterization, anticancer, antibacterial, anti-diabetic and anti-inflammatory activities of green synthesized silver nanoparticles using Justica wynaadensis leaves extract. Materials Today: Proceedings, 46(13): 5942-5947.
Lingaraju D, Sudarshana M, Rajashekar N (2013). Ethnopharmacological Survey of Traditional Medicinal Plants in Tribal areas of Kodagu District, Karnataka, India. J. Pharm. Res. 6: 284-297.
Luzia KAML, Aline HS, Glauce Socorro de Barros Viana (2017). Justicia pectoralis, a coumarin medicinal plant have potential for the development of antiasthmatic drugs? Revista Brasileira de Farmacognosia. 27(6): 794-802.
Nigudkar M, Patil N, Sane R and Datar A (2014). Preliminary phytochemical screening and HpTLC fingerprinting analysis of Justicia wynaadensis (Nees) And. Int. J. Pharma Sci. 4(3): 601-605.
Patil N, Nigudkar M, Sane R, Ajitkumar BS, Datar A (2015). Evaluation of microscopic structure of Justicia wynaadensis and the stability of its color extracted by using conventional and microwave extraction method. J Food Sci. Technol. 52(10): 6455-64.
Ponnamma S and Manjunath K (2012). High frequency induction and regeneration of multiple shoots from nodal explants of Justicia wynaadensis (Nees) T. Anders Int. J. Curr. Res. 4: 40-43.
Ponnamma SU and Manjunath K (2012). GC-MS Analysis of Phytocomponents in the Methanolic Extract of Justicia Wynaadensis (Nees) T. Anders. Int. J. Pharm. Bio Sci. 3(3): 570 - 576.
Ponnamma SU and Manjunath K (2015). TLCBioautography guided screening for compounds inhibitory to Klebsiella pneumonia from Justicia wynaadensis (Nees) T.Anders. Ind. J. of Appl. Res. 5(4).
Sahana Chavan CS, Ramakrishna R, Saraswathi Raman DN, Somashekaraiah BV (2019). Phytochemical analysis and in vitro antioxidant activity of extracts of Justicia wynaadensis leaves. Research J. Pharm. and Tech. 12(8): 3643-3648.
Saini V, Gangwar LD. (2023). A Review Article for Medicinal uses of Justicia wynaadensis. International Journal of Pharmaceutical Research and Applications. 8(1):1573-1576
Subbiah MTR, Norman EJ (2002). Rain Forest Plant Extract with Cellular Cholesterol Lowering Properties. United States Patent, 6: 365-411.
Sudha M, Geetha RJ Singh, Vaishnavi R (2011). The phytochemical and antioxidant screening of Justicia wynaadensis. African J. Plant Sci. 5(9):489-492.
Sujatha SS and Thrupthi N (2020). Review Literature on Justicia wynaadensis. Int. J. Adv. Res. Inn. Ideas in Educ. 6(4): 1503-1507.
Vandana CD and Shanti KN (2017). Cytotoxic activity of Justicia wynaadensis (Nees) T. Anderson leaf extract on Human Cancer Cell lines. Int. J. Pharm. Sci. Res. 8(12): 5298-5302.
Vandana CD, Shanti KN, Shantha SL (2018). GC-MS analysis of callus and leaf extracts of in vitro propagated plants of Justicia wynaadensis (Nees) T. Anderson. Int. J. Pharm. Sci. Res. 9(2): 535-543.
Vandana CD, Shanti, KN, Prashantha K Vivek C (2020). In silico studies of bioactive phytocompounds with anticancer activity from in vivo and in vitro extracts of Justicia wynaadensis (Nees) T. Anderson. Int. J. Comp. Biol. Drug Desn. 13:5-6.
Vidyabharathi BP (2012). Assessment of antiinflammatory activity of Justicia wynaadensis, a medicinal plant. International Conference on Biodiversity and Sustainable Energy Development, Hyderabad International Convention Center, India.
Vishma BL, Sujayraj RS, Prashantha N (2015). Antioxidant and Genoprotective studies of the leaf extract of Justicia wynaadensis (Nees) in Conference: National Seminar on Life and Life Processes: Sustainable Development.